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1 Engs paper, published in the Journal of Biological Chemistry , noted something strange: exendin-4 shared 53% of its amino acid sequence with a human gut hormone called glucagon-like peptide-1 (GLP-1), which had been characterized just a few years earlier

PMCID: PMC4021346

This connection is rooted in several age-related physiological changes that directly impinge on the core regulatory axes of ferroptosis

This has been associated with an increased risk of small intestinal bacterial overgrowth (SIBO), which can cause diarrhea

GLP-1 medications also have the potential to worsen reflux, increase constipation, and, sometimes, cause diarrhea