doi: 10.1177/1090820X13485239
Comments: Subcutaneous semaglutide 1 mg / week: 13 % improvement in walking distance vs placebo (med 26.4 m / avg 39.9 m) Improved quality of life (VascuQoL-6 and SF-36 questionnaires) Fewer rescue treatments vs placebo Improvement in ankle-brachial index (ABI) Modest weight loss of 4.1 kg with Semaglutide vs placebo Key benefits: Rapid benefit (from week 26) maintained over time (up to week 57) Improved performance on inclined treadmill Increased ABI, supporting a direct vascular benefit (anti-inflammatory action) Potential additional benefits: weight loss, cardiometabolic effects, renal benefits, major cardiovascular event reduction, heart failure benefits Limitations: Difficulty translating treadmill improvement to daily life activities Benefits may vary based on disease severity, functional demands, and patient expectations Study limited to diabetic patients Short-term evaluation of adverse major events Modest but statistically significant improvement in ABI warrants further mechanistic studies on PAD Other considerations: Weight loss and gastrointestinal effects may have revealed randomization, but unlikely to affect objective measures (walking distance or ABI) Other available medications: Pentoxifylline : Few benefits compared to placebo Cilostazol : Similar clinical improvement to Semaglutide Both increase walking distance without impact on cardiovascular health Get the latest clinical cases and breaking news delivered straight to your inbox!
Keep at room temperature (below 30C), away from moisture and heat Do not remove from the original pack until due to take your dose Keep out of the reach of children and pets Check the expiry date before every new supply If you have any unused or expired tablets, take them to your local pharmacist for safe, environmentally-responsible disposal
In addition, exogenous administration of lactate reduced brain lesion size in a rat controlled cortical impact models of TBI (Alessandri et al., 2009, 2013
Both iron and folate may be needed so please have these levels checked by your doctor
