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Optical Rotation, Specific Rotation 781S Sample solution: 40 mg/mL in water Acceptance criteria: 15.5 to 17.5 , at 20 ASSAY Procedure Sample: 500 mg of glutathione previously dried Titrimetric system (See Titrimetry 541 .) Mode: Direct titration Titrant: 0.1 N iodine VS Endpoint detection: Visual Blank: 50 mL of metaphosphoric acid (1 in 50) Analysis: Dissolve the Sample in 50 mL of metaphosphoric acid (1 in 50) and titrate with the Titrant

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Another study showed that acute administration of exenatide was associated with increased hepatic glucose uptake during an oral glucose tolerance test (OGTT) and a reduction in endogenous glucose production, reinforcing the hypothesis of a direct action of GLP-1 on the liver [12]

Continue this stepwise escalation by 2.5 mg every 4 weeks as tolerated, with goal of reaching 10 mg or 15 mg depending on response and tolerability

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