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It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients
There is every reason to expect new treatment possibilities to continue emerging
Individuals with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or pancreatitis should avoid using tirzepatide
| DOI: 10.4103/iju.IJU_15_17 Lenzi A, Culasso F, Gandini L, Lombardo F, Dondero F
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