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The Phase 3 TRIUMPH-4 trial (NCT05869903) enrolled adults with obesity and knee osteoarthritis

It stimulates fibroblasts (the cells responsible for producing collagen and elastin) to produce these structural fibers that are the building blocks of firm, elastic skin

For instance, paeoniflorin directly binds to the glycolytic enzyme ENO1, inhibiting its activity and expression, thereby disrupting glucose metabolism and suppressing M1 polarization in microglia and macrophages, which alleviates central inflammation in experimental autoimmune encephalomyelitis (247)

This approach aligns with core concepts of precision nutrition (166)

Figure 12 Based on experimental results, a 24-h incubation with 1 mM FFAs was selected to induce the NASH cell model, with 1 M and 2 M THC used as low and high doses, respectively