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The average participant entering Phase 2 Retatrutide trials had a BMI of 37.5, a starting weight around 231 lbs, and the majority carried at least two of the above metabolic risk factors
Oxidative stress has clear links with many diseases, including cancers and heart disease
Semaglutide remains a best-in-class tool for strong, steady weight loss (up to 17%), boasts the longest track record of safety data, and has proven cardiovascular event reduction in high-risk patients
Given that participants had not yet reached a weight plateau at the time the study ended, it appears that full weight reduction was not yet attained
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