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Randomization and masking Randomization (1:1) to semaglutide 2.4 mg or placebo was done centrally by the clinical research organization (Parexel) in a double-blind manner using an interactive web-based response system (IWRS) with a fixed-size blocking schema, without stratification
Reference: Lhteenvuo M, Tiihonen J, Solismaa A, Tanskanen A, Mittendorfer-Rutz E, Taipale H
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An additional post-hoc sensitivity analysis was performed by excluding the ITCA 650 trial [9] to investigate both primary and secondary outcomes to validate the robustness of the pooled analysis (Supplementary Appendix D)
