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BMJ Open
Certain individuals are at a higher risk for B12 deficiencyincluding those following strict vegan or vegetarian diets, as well as patients with conditions that impair nutrient absorption, such as pernicious anemia, celiac disease, Crohns disease, or a history of gastrointestinal surgery
In a Phase 2b obesity trial , AOD-9604 did not produce statistically significant weight loss versus placebo , and pharmaceutical development was discontinued around 2007 [3] [4]
This early response may reflect the body's immediate utilisation of available B12 for urgent metabolic processes
By influencing NNMT-associated pathways, it serves as a valuable tool in in vitro studies examining metabolic regulation, mitochondrial function, and potential applications in obesity and age-related research contexts
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