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Sachdev, E., Tabatabai, R., Roy, V., Rimel, B

While albiglutide demonstrated good glycemic efficacy and tolerability, adverse effects included upper respiratory tract infections, diarrhea, nausea, and injection site reactions

Moreover, SCFAs such as acetate can remodel macrophage glycolysis, activate the hypoxia-inducible factor 1 (HIF-1) axis and NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, thereby increasing interleukin-1 (IL-1) and nitric oxide production and enhancing pulmonary innate immunity (Machado et al., 2022)

W.VictorM

Indeed, previous reports indicate that GLP-1R signaling is blunted when dynamin-dependent endocytosis is inhibited chemically 10 or genetically 56