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NDP-MSH treatment significantly altered the expression of various transcripts, including chemokines, receptors, and cell cycle mediators, influencing critical signaling pathways like the interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)/suppressor of cytokine signaling (SOCS) axis

However, Sp-L-DOPA combination showed consistent negative geotaxis even during the wearing-off phase, representing substantial alleviation of L-DOPA toxicity and promotion of enhanced mitochondrial and cellular health in dopaminergic neurons

Challenges and Future Directions While the preliminary results of 5-Amino-1MQ are promising, its essential to acknowledge that the journey from preclinical studies to human applications is complex