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However, the effects of the BASs on GLP-1 secretion are controversial
In patients with type 2 diabetes, the ability of their bodies to respond to GLP-1 and stimulate insulin secretion is reduced, Quinones explains
At 48 weeks on 12mg: Visceral fat: -42% reduction (more than total weight loss percentage) Liver fat: -50% reduction based on imaging studies Subcutaneous fat: -28% reduction The fact that visceral and liver fat dropped faster than overall weight helps explain retatrutide's metabolic improvements
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In osteoarthritis, pain relief is often attributed to weight loss rather than direct analgesic effects, complicating the evaluation of GLP-1RAs efficacy
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