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Specifically, CAR T cells in the day 28 BM of LTR had significantly higher expression of mTOR, pS6, pAKT (mTOR and pAKT pathways) and the metabolic sensor AMPK, as well as significant increases in the fermentative glycolysis enzyme LDHA, the endogenous fatty acid metabolism enzymes SCD1, LAL, and CD45RA, suggesting an effector immunometabolic phenotype

Research involving these pathways remains ongoing, particularly within broader investigations involving cellular-response mechanisms, oxidative-stress regulation, and tissue-maintenance research

2i and Supplementary Fig

Alteration of mitochondrial proteome due to activation of Notch1 signaling pathway