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In addition, a multicenter, randomized controlled trial in patients with T2DM without cardiovascular disease also found that the mean carotid intimal thickness and left carotid intimal thickness after sitagliptin treatment were significantly reduced from baseline, with no significant difference on the right side

[1] The results were exciting: [1] While L-citrulline alone increased plasma arginine, the combination with glutathione was most effective at increasing plasma nitrite and nitric oxide metabolites (NOx)

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It plays a crucial role in the livers detoxification processes