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An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]

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The first pass through the liver and stomach acids destroy much of that which is taken by mouth

Anti-inflammatory effects include reduction of TNF- and IL-6 in IBD models, contributing to a measurable drop in macroscopic and microscopic damage scores