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Trulicity EPAR product information
This reaction is essentially a reversal of the thiolase (HADHB or ACAA2) catalyzed reaction of fatty acid -oxidation but is in fact catalyzed by the mitochondrial enzyme acetoacetyl-CoA thiolase (encoded by the ACAT1 gene)
Using GLP-1 RAs alongside other glucose-lowering or cardiovascular medications can significantly enhance therapeutic outcomes, reduce side effects, and better address the diverse needs of different patients
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After a certain point, energy is also drawn from fatty acids
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