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In contrast, long-acting agents appear to have a larger effect on lowering fasting glucose due to their effect to increase insulin release and inhibit glucagon release (Meier 2012)

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Patients may notice return of hyperglycemia symptoms such as increased thirst, frequent urination, and fatigue

Because evidence is limited, people who are pregnant or breastfeeding, have significant medical conditions, take prescription medications, or have a history of reactions to injectable therapies should discuss NAD+ treatment with their healthcare professional rather than relying on generalized wellness advice