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Glutathione plays a significant role in maintaining the redox (reduction-oxidation) balance in cells, but GSNO and GSSG each have unique characteristics: S-Nitroso-L-glutathione (GSNO): GSNO is a nitric oxide (NO) donor in cells, and it is part of the group of S-nitrosothiols
Therefore, targeting glucose metabolism holds promise not only for directly suppressing tumor growth but also for enhancing the efficacy of other therapeutic modalities through metabolic synergy or mechanistic complementation [122]
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have demonstrated that homozygous carriers of SLC47A1 rs2289669 A-allele show a larger reduction in HbA1c to metformin therapy compared to the prevalent G-allele (Becker et al., 2009a)
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