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Exendin-4 (exenatide) became the first clinically-approved GLP-1R agonist (2005) for treatment of T2D

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Furthermore, roGFP2 fusion constructs with wild-type and mutant enzymes allow the intracellular analysis of enzyme mechanisms and structure-function relationships 15,34,35,75

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Unfortunately, the study was prematurely terminated and underpowered, which precludes a conclusive determination of the disease-modifying effects of exenatide for MCI or early AD in clinical settings [95]

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