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Their safety and effectiveness haven't been established

This means that quality, consistency and safety depend heavily on the clinical oversight involved

Neurophysiological changes in the central and peripheral nervous system of streptozotocin-diabetic rats

S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1 [PMID: 28709872] Laboratory literature summary: S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1

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