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In addition, the mRNA and protein levels of SIRT1 in RA LFS are lower than normal FLS, and increased SIRT1 expression strikingly suppresses the invasiveness of RA FLS by inhibiting MMP1 and MMP13 expression (303)

2019 Mar 1;102(2):395-411

[6] NAD+ augmentation may counteract age-related NAD+ loss caused by overactive NAD-consuming enzymes (such as the NADase CD38), thereby supporting mitochondrial maintenance and metabolic homeostasis

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