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Cur Drug Disc Technol 20:7488

If possible, also track waist circumference weekly, body composition monthly (through DEXA or bioimpedance), and blood markers quarterly (fasting glucose, HbA1c, lipid panel, liver enzymes)

Faster Metabolic Response Both clinical participants and preclinical models reach clinically relevant weight-loss thresholds more rapidly than with comparator treatments

Patients often report a dramatic drop in joint pain and morning stiffness within the first few weeks of starting a GLP-1long before significant body weight has been lost

Triple agonists such as retatrutide target GLP-1, GIP, and glucagon receptors and are still investigational