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Marketed under the brand name Zepbound for weight loss, tirzepatide is also approved as Mounjaro for type 2 diabetes management
The most frequently reported effects involve the digestive system and are particularly common when treatment begins or after the dose is increased
30,31 Due to the degradation of peptide-based drugs by proteolytic enzymes, the low permeability of intestinal epithelium, and the low pH of the gastrointestinal tract, oral administration of semaglutide is challenging
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