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Such observations prompted the investigation into the potential metabolic benefits of GLP-1R and GCGR co-activation (114, 115), which led to the subsequent development of GLP-1R/GCGR co-agonists (73, 116) and, later, GIPR/GLP-1R/GCGR tri-agonists (117)

By capitalizing on their unique attributes, these advanced gene editing systems, in conjunction with optimized NP delivery, hold promise for enhancing the precision and efficacy of cancer gene therapy, paving the way for more tailored and safer therapeutic strategies

Metabolites as signalling molecules

doi: 10.3390/antiox9060518 189 MeftahiG