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Of the 48 inter-molecular NOE restraints, only 2 NOEs could be assigned unambiguously and correspond to contacts between p53-Trp53 HE# - FOXO4-Leu160 HD# and p53-Trp53 HD#FOXO4-Leu109 HD# (Supplementary Note 1)

All administered garlic preparations (garlic powder, aged garlic extract, garlic oil, and fresh garlic) were well tolerated and associated with only minor side effects (garlic odor and mild gastrointestinal discomfort) (93)

325 Moreover, the activation of SIRT1 also inhibits the senescence of dermal fibroblasts induced by ultraviolet irradiation

Flow cytometry Cells were collected, washed twice with PBS, and stained using 5 l of 7-AAD (BD Biosciences, #559925) and 5 l of annexin V-FITC (BD Biosciences, #556420) in 100 l of annexin V binding buffer (BD Biosciences, #556454) per sample

It is not approved as a drug, supplement, or food ingredient in the US, EU, Australia, and similar markets