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In contrast, TNF- and IL-1 secreted by M1 macrophages stimulate fibroblasts to secrete excessive extracellular matrix, leading to matrix deposition and maladaptive fibrosis (249)

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While ETC is the source of superoxide, the existence of mitochondrial NO synthase (mtNOS) that provides the NO required to form peroxynitrite is controversial

We used qRT-PCR to quantify the relative expression of PLIN1, 2, and 3 and estimate the lipid accumulation in response to OA and EX-4 treatments

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