Rapid weight reductionexceeding 12 pounds per weekmay be associated with greater proportional loss of lean body mass
In this trial, only vitamin E met the prespecified significance level of the primary outcome (i.e., improvement in histological findings, which included an improvement in hepatocellular ballooning), although both active treatment groups had a significant reduction in steatosis, lobular inflammation, and NAS (NAFLD activity score)
Then, increase the dose gradually
"Insulin requirements are often lower in individuals with type 1 using a GLP-1 receptor agonist," said Dr
Tirzepatide stimulates GLP-1 and GIP receptors, enhancing insulin secretion, slowing gastric emptying, and promoting satiety