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Current findings on the efficacy of incretin-based drugs for diabetic kidney disease: a narrative review

SCFAs do this by activating G-protein-coupled receptors (such as GPR41 and GPR43) on L-cells, triggering intracellular signaling that increases GLP-1 release

Nathan BM, Rudser KD, Abuzzahab MJ, Fox CK, Coombes BJ, Bomberg EM, et al

Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)

This prescription requirement means your dosage chart should match what your provider ordered