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Strong response suggests maintaining current dosing

The use of proton pump inhibitors (PPIs) has been associated with an increased risk of vitamin B12 deficiency, particular in older adults and those on long-term PPI therapy. Nutrition Reviews Duration-Dependent Risk Assessment The risk of B12 deficiency from PPIs grows with time

Ongoing studies explore its influence on cellular communication pathways associated with nutrient utilization, energy balance, and metabolic adaptation

These factors contribute to better reproducibility in research and reduced variability in results

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