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Additionally, the SARS-CoV-2 nucleocapsid (N) protein physically binds Smad3 to promote its phosphorylation and nuclear translocation, thereby triggering the Smad3-RIPK3-MLKL pathway to induce severe tubular necroptosis and kidney injury in diabetic models (138)

doi: 10.1016/j.fertnstert.2022.04.027 18 MaRLDengYWangYFZhuSYDingXSSunAJ

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