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Individuals with autosomal recessive familial hyperinsulinism, caused by mutations in either ABCC8 or KCNJ11 (FHI-KATP), tend to be large for gestational age and usually present with severe refractory hypoglycemia in the first 48 hours of life
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Sigma Aldrich) and then purified following the cleanup protocol of RNeasy Mini kit (Qiagen), similar to our previous reports 65,76,77
Evaluation for other etiologies (fibroids, polyps, thyroid dysfunction, perimenopause) is warranted
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