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Tirzepatide was on the FDA drug shortage list for an extended period as demand for Mounjaro and Zepbound far exceeded manufacturing capacity

Individual results vary based on starting body composition, diet adherence, exercise intensity, and metabolic factors

Insulin and Other Diabetes Medications Because semaglutide affects blood sugar levels, combining it with insulin or other diabetes medications can lead to hypoglycemia (low blood sugar)

Adherence in trials is artificially high for instance, 92.8% of patients in a 2-year semaglutide trial completed the study (source)

Most combination studies involve older obesity medications (e.g., orlistat with phentermine), not modern GLP-1 agents