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For safety, any semaglutide that appears unusual or has passed its beyond-use date should be discarded
Whilst these multi-agonists have not yet been licensed for use in people with T2D and/or obesity, preclinical and early clinical trials support a future role for their use [38]
Previous studies have also demonstrated that GLP-1R agonists exendin-4 (Ex4) induced diuresis and natriuresis by increasing GFR and inhibiting the main renal proximal tubule sodium reabsorption in normotensive rats (101, 102)
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