for some of the changes, it has been demonstrated that they increase the concentration of the so-called inactive B12, but not the active B12
No human clinical trials exist
The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods
Meanwhile, overall aging indicators were significantly improved: locomotor activity and endurance were enhanced, hair gloss increased, levels of aging-related inflammatory factors (such as TNF-, IL-6) decreased, and the average lifespan of mice was prolonged
While preliminary findings suggest the safety of 5-amino-1MQ, clinical data is still lacking, and continuous scrutiny is essential for researchers to understand its effects across diverse demographic groups