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Blood 106:142a, 2005
Retatrutide is the first medication to mimic three hormones, GLP-1, GIP and glucagon, rather than the one or two that current medications use
Three oral GLP-1 options exist in 2026: Rybelsus (oral semaglutide, approved 2019 for type 2 diabetes), an oral semaglutide formulation for weight management approved in early 2026, and Foundayo (orforglipron), Eli Lilly's small-molecule agent approved April 1, 2026 for chronic weight management at $149 per month through LillyDirect
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